Interleukin-1[beta] drives prostate cancer cell cooperation in the bone metastatic niche

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Title: Interleukin-1[beta] drives prostate cancer cell cooperation in the bone metastatic niche
Author(s): Shahriari, Kristina S.
Advisor(s): Fatatis, Alessandro
Keywords: Pharmacology; Physiology; Pharmacological and Toxicological Phenomena and Processes; Physiological Phemonena
Date: 2016-08
Publisher: Drexel University
Thesis: Ph.D., Pharmacology and Physiology -- Drexel University, 2016
Abstract: Advanced prostate cancer frequently leads to bone metastasis, a major cause of morbidity and mortality. In this study, we reveal a novel phenomenon in which interleukin-1[beta] derived from one population of disseminated prostate cancer cells conditions the bone microenvironment to enable metastatic colonization by a diverse cohort of prostate cancer cells. We propose that this cooperation among cancer cells demonstrates a functional role for phenotypic heterogeneity in human bone metastasis, which may be clinically exploited for the benefit of patients with metastatic prostate adenocarcinoma.
URI: http://hdl.handle.net/1860/idea:7175
In Collections: Theses, Dissertations, and Projects

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