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3D Microtomographic Characterization of Precision Extruded Polycaprolactone Scaffolds
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|Title: ||3D Microtomographic Characterization of Precision Extruded Polycaprolactone Scaffolds|
|Authors: ||Darling, Andrew Leete|
|Keywords: ||micro-CT;tissue engineering;porosity;polycaprolactone;microarchitecture|
|Issue Date: ||2004|
|Publisher: ||Wiley Periodicals, Inc.|
|Citation: ||Journal of Biomedical Materials Research Part B: Applied Biomaterials. V. 70B, Issue 2, 2004, pp. 311-317. Retrieved April 2006 from http://www.pages.drexel.edu/~sunwei/WSUN-Papers/JBMR-3DM-PCL.pdf|
|Abstract: ||One of the dominant approaches to tissue engineering is the seeding of biodegradable,
biocompatible polymer scaffolds with progenitor cells prior to 3D culture or implantation.
The microarchitecture of these scaffolds has direct effects upon the ability of cells to
attach, migrate, and differentiate. Microtomographic (micro-CT) scanners enable high-speed
3D characterization of the salient features of these polymer scaffolds. A micro-CT scan
followed by 3D reconstruction of serial image sections can determine porosity, pore size, pore
interconnectivity, strut size, and overall 3D microarchitecture. In this study, four polymer
samples with different microarchitectures were manufactured through precision extrusion
deposition free-form fabrication and subsequently characterized through micro-CT analysis.
A desktop micro-CT scanner was used to examine each sample at approximately 19.1-micron
resolution. 2D analyses and 3D reconstructions of core regions of each sample were performed.
These results illustrate that qualitative and quantitative analysis of polymer scaffolds
is possible using micro-CT and 3D reconstruction techniques.|
|Appears in Collections:||Faculty Research and Publications (MEM)|
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