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Please use this identifier to cite or link to this item: http://hdl.handle.net/1860/3016

Title: Covalent and ionic modification of biopolymers for design properties
Authors: Szewczyk, Janah Cecelia
Keywords: Materials science;Biopolymers;Polymers -- properties
Issue Date: 2-Jun-2009
Abstract: Polysaccharides are abundant in availability, bioderived and intrinsically biocompatible. Chitosan, alginate, hyaluronic acid and chondroitin sulfate have seen a significant breadth of research in recent years. In their native form these natural polymers are used in unique applications such as metal ion absorption, rheological, drug delivery, and wound healing among others. The modification of polysaccharides has the ability to alter the properties that define these applications, such as the manner in which the polymer acts in solution, the pH and temperature response of the modified polymer, and its propensity for binding to specific metal ions. Two types of modifications are investigated. The use of carbodiimide chemistry to covalently attach small molecules and peptides to chitosan, alginate, hyaluronic acid and chondroitin sulfate is described. The characterization, analysis, and methodology via FTIR and UV/Vis among other techniques are explained. Due to the characterization techniques chosen confirmatio of the individual reactions was easier and done with more confidence if the modifier contained thiol functionality. Hyaluronic acid was ionically modified with glycerol phosphate and tripolyphosphate. The resulting rheological performance is presented. The reaction to the phosphate modified polymer to varying temperature and pH environments is described and compared to published results for chitosan variants.
URI: http://hdl.handle.net/1860/3016
Appears in Collections:Drexel Theses and Dissertations

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