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Universal metastability of sickle hemoglobin polymerization
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http://hdl.handle.net/1860/2832
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| Title: | Universal metastability of sickle hemoglobin polymerization |
| Authors: | Weng, Weijun |
| Keywords: | Biophysics
Sickle cell anemia
Hemoglobinopathy |
| Issue Date: | 11-Jul-2008 |
| Abstract: | Sickle hemoglobin (HbS) is a natural mutation of the normal hemoglobin (HbA) found in the red blood cells of human body. Polymerization of HbS occurs when the concentration of deoxyHbS exceeds a well-defined solubility, which is the underlying cause of the Sickle Cell Disease. It has long been assumed that thermodynamic equilibrium is reached when polymerization comes to an end. However, in this thesis we demonstrate that in confined volume as well as in bulk solution, HbS polymerization terminates prematurely, leaving the solution in a metastable state. A newly developed Reservoir method as well as modulated excitation method were adopted for the study. This discovery of universal metastability gives us new insights into understanding the mechanism of sickle cell disease. |
| URI: | http://hdl.handle.net/1860/2832 |
| Appears in Collections: | Drexel Theses and Dissertations
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