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Validation of high gradient magnetic field based drug delivery to magnetizable implants under flow
Please use this identifier to cite or link to this item:
http://hdl.handle.net/1860/2748
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| Title: | Validation of high gradient magnetic field based drug delivery to magnetizable implants under flow |
| Authors: | Forbes, Zachary G.
Yellen, Benjamin B.
Halverson, Derek S.
Fridman, Gregory
Barbee, Kenneth A.
Friedman, Gary |
| Keywords: | Magnetic Drug Delivery
Magnetic Separation Cardiovascular Disease
Stents |
| Issue Date: | Feb-2008 |
| Publisher: | Institute of Electrical and Electronics Engineers (IEEE) |
| Citation: | IEEE Transactions on Biomedical Engineering, 55(2): pp. 643-649. |
| Abstract: | The drug-eluting stent’s increasingly frequent occurrence
late stage thrombosis have created a need for new strategies
for intervention in coronary artery disease. This paper demonstrates
further development of our minimally invasive, targeted
drug delivery system that uses induced magnetism to administer
repeatable and patient specific dosages of therapeutic agents to specific
sites in the human body. Our first aim is the use of magnetizable
stents for the prevention and treatment of coronary restenosis;
however, future applications include the targeting of tumors, vascular
defects, and other localized pathologies. Future doses can
be administered to the same site by intravenous injection. This
implant-based drug delivery system functions by placement of a
weakly magnetizable stent or implant at precise locations in the
cardiovascular system, followed by the delivery of magnetically
susceptible drug carriers. The stents are capable of applying high
local magnetic field gradients within the body, while only exposing
the body to a modest external field. The local gradients created
within the blood vessel create the forces needed to attract and hold
drug-containing magnetic nanoparticles at the implant site. Once
these particles are captured, they are capable of delivering therapeutic
agents such as antineoplastics, radioactivity, or biological
cells. |
| URI: | http://dx.doi.org/10.1109/TBME.2007.899347
http://hdl.handle.net/1860/2748 |
| Appears in Collections: | Faculty Research and Publications (ECE)
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