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A systems approach for the prediction of wild type MAPK pathway response to targeted drugs
Please use this identifier to cite or link to this item:
http://hdl.handle.net/1860/2723
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| Title: | A systems approach for the prediction of wild type MAPK pathway response to targeted drugs |
| Authors: | Miller, David J.
Ghosh, Avijit |
| Issue Date: | Oct-2007 |
| Citation: | Paper presented at the Eighth International Conference on Systems Biology, Long Beach, CA. |
| Abstract: | In this paper we simulate the wild type MAPK pathway response to twelve in silico drugs
that were previously found to reduce elevated phosphorylated ERK levels (ERK*) in 40 top
ranked mutations in a model of the MAPK signal transduction pathway. We nd that a
subset of the simulated drugs (notably those targeting GEF and the G
G-protein trimer)
were able to e ectively inhibit the elevated ERK* levels of the mutated pathways, whilst
simultaneously eliciting only minimal inhibition of the wild type pathway ERK* response to
EGF stimulation. |
| URI: | http://hdl.handle.net/1860/2723 |
| Appears in Collections: | Faculty Research and Publications (Physics)
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