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The epidemiology of autism spectrum disorders
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|Title: ||The epidemiology of autism spectrum disorders|
|Authors: ||Newschaffer, Craig J.|
Croen, Lisa A.
Grether, Judith K.
Levy, Susan E.
Mandell, David S.
Miller, Lisa A.
Reynolds, Ann M.
Rice, Catherine E.
Windham, Gayle C.
|Issue Date: ||8-Jan-2007 |
|Publisher: ||Annual Reviews|
|Citation: ||Annual Review of Public Health, 28(1): pp. 235-258.|
|Abstract: ||Autism spectrum disorders (ASDs) are complex, lifelong, neurodevelopmental
conditions of largely unknown cause. They are much
more common than previously believed, second in frequency only to
mental retardation among the serious developmental disorders. Although
a heritable component has been demonstrated in ASD etiology,
putative risk genes have yet to be identified. Environmental risk
factors may also play a role, perhaps via complex gene-environment
interactions, but no specific exposures with significant population
effects are known. A number of endogenous biomarkers associated
with autism risk have been investigated, and these may help identify
significant biologic pathways that, in turn, will aid in the discovery of
specific genes and exposures. Future epidemiologic research should
focus on expanding population-based descriptive data on ASDs, exploring
candidate risk factors in large well-designed studies incorporating
both genetic and environmental exposure data and addressing
possible etiologic heterogeneity in studies that can stratify case
groups and consider alternate endophenotypes.|
|Appears in Collections:||Faculty Research and Publications (Epidemiology and Biostatistics)|
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