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A user friendly multiscale lung modeling suite and application
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http://hdl.handle.net/1860/2581
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| Title: | A user friendly multiscale lung modeling suite and application |
| Authors: | Shah, Viraj Nignesh Leena |
| Keywords: | Biomedical engineering
Lungs--Computer simulation
Respiration--Mathematical models |
| Issue Date: | 17-Jan-2008 |
| Abstract: | The development of computational lung models and the functional simulation of gas transport is a promising avenue to investigate the effects of structural alterations as they relate to disease and aging on the lung function. Since many changes such as emphysema originate from the respiratory units (acini), which are the end units of the bronchial tree, predictions about the impact on the lung function on this level of organization critically rely on a precise modeling of the entire lung. The computational modeling suite, which extends previous versions by a user friendly interface based on QT, allows modifying structural properties and executing functional simulations of the entire lung including the respiratory units. Application of this utility is demonstrated for emphysema, a disease and aging related condition with an abnormal permanent enlargement of air spaces with the destruction of cell walls leading to decrease in the alveolar surface area to volume ratio. The results demonstrate the predictability of loss in function such as oxygen uptake and change in gas concentration profiles over the breathing cycle with the severity of the disease. |
| URI: | http://hdl.handle.net/1860/2581 |
| Appears in Collections: | Drexel Theses and Dissertations
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