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Please use this identifier to cite or link to this item: http://hdl.handle.net/1860/2560

Title: Locally targeted drug delivery to magnetic stents for therapeutic applications
Authors: Forbes, Zachary Graham
Halverson, Derek S.
Fridman, Gregory
Yellen, Benjamin Biron
Chomy, M.
Friedman, Gary
Barbee, Kenneth A.
Keywords: Drug Delivery;Magnetic Targeting;Stent
Issue Date: 2004
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Citation: Paper presented at he 2004 IEEE/EMBS International Summer School on Medical Devices and Biosensors, ISSS-MDBS 2004, Hong Kong, China.
Abstract: The ability to safely and effectively deliver high dosages of drugs to specific sites in the human body is fundamental to the advancement of drug delivery research. Drugs with proven effectiveness under in vitro investigation often reach a major roadblock under in vivo testing due to a lack of an effective delivery strategy. In addition, many clinical scenarios require delivery of agents that are therapeutic at the desired delivery point, but otherwise systemically toxic. This paper proposes a method for targeted drug delivery by applying high magnetic field gradients within the body to an injected superparamagnetic colloidal fluid carrying a drug, without relying on magnetic coils held external to the body to provide the force. The experimental flow model presented gives insight into the use of magnetic carriers for site-specific delivery of therapeutic agents.
URI: http://dx.doi.org/10.1109/ISSMD.2004.1689549
Appears in Collections:Faculty Research and Publications (ECE)

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