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Optimal hydrogels for fast and safe delivery of bioactive compounds
Please use this identifier to cite or link to this item:
http://hdl.handle.net/1860/2529
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| Title: | Optimal hydrogels for fast and safe delivery of bioactive compounds |
| Authors: | Gadkari, Siddharth B. |
| Keywords: | Biomedical engineering
Colloids in medicine
Bioactive compounds |
| Issue Date: | 27-Dec-2007 |
| Abstract: | The design of injectable, biocompatible hydrogels encapsulating bioactive substances and exhibiting minimal aerosol formation is an important problem and its optimal solution can lead to more effective delivery vehicles in various applications. The delivery rate from such hydrogels is generally slow if one targets minimal aerosol formation. This thesis explores different biomaterials as potential hydrogels for such applications. The design criteria are good extrusion consistency without phase separation, fast release rate of the encapsulated biomolecule and ability to maintain the functionality of the encapsulated entity. In vitro tests were developed to evaluate the hydrogels synthesized. We were able to develop a gel showing good extrusion consistency and fast release rate of an active virus. |
| URI: | http://hdl.handle.net/1860/2529 |
| Appears in Collections: | Drexel Theses and Dissertations
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