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Behaviorally modulated filter model for the thalamic reticular nucleus
Please use this identifier to cite or link to this item:
http://hdl.handle.net/1860/1703
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| Title: | Behaviorally modulated filter model for the thalamic reticular nucleus |
| Authors: | Scaglione, Alessandro
Moxon, Karen A. |
| Issue Date: | Aug-2006 |
| Publisher: | Institute of Electrical and Electronics Engineers (IEEE) |
| Citation: | Proceedings of the 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06: pp. 595-598. |
| Abstract: | Incoming sensory information is first processed in
the thalamocortical network. Previous studies showed that the
responses generated in the nuclei of this network are
behaviorally modulated, suggesting that the processing of the
somatosensory information could be state dependent. Most
theories, proposed to describe this response modulation have
postulated that the thalamic reticular nucleus (TRN) plays a
role in this response modulation. We suggest that the TRN acts
as a bandpass filter whose bandwidth increases or decreases
depending on the state of the animal. To test this idea, we used
multineuron recordings and demonstrate, for the first time,
that the responses of single neurons in the reticular nucleus are
modulated by the behavior of the animal. This result, taken
together with the anatomy of the thalamocortical network and
previous studies on anesthetized rats, suggests that the
modulation of the responses in the thalamus and cortex could
be at least partially due to the TRN through a mechanism that
is similar to that of a behavioral modulated filter. |
| URI: | http://dx.doi.org/10.1109/IEMBS.2006.260583
http://hdl.handle.net/1860/1703 |
| Appears in Collections: | Faculty Research and Publications (Biomed Eng)
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