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3-mercaptopropyltrimethoxysilane as insulating coating and surface for protein immobilization for piezoelectric microcantilever sensors
Please use this identifier to cite or link to this item:
http://hdl.handle.net/1860/1657
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| Title: | 3-mercaptopropyltrimethoxysilane as insulating coating and surface for protein immobilization for piezoelectric microcantilever sensors |
| Authors: | Capobianco, Joseph A.
Shih, Wan Y.
Shih, Wei-Heng |
| Issue Date: | 2007 |
| Publisher: | American Institute of Physics |
| Citation: | Review of Scientific Instruments, 78(4): pp. 046106. |
| Abstract: | We have examined coating PbMg1/3Nb2/3O3 0.63– PbTiO3 0.37 PMN-PT /tin and lead zirconate
titanate PZT /glass piezoelectric microcantilever sensor PEMS with 3-mercaptopropyltrimethoxysilane
MPS by a simple solution method to electrically insulate the PEMS for in-water
applications. In contrast to earlier methytrimethoxysilane insulation coating, the MPS coating also
facilitated receptor immobilization on the sensor surface via bonding of its sulhydryl group to a
bifunctional linker, sulfosuccinimidyl-4- N-maleimidomethyl cyclohexane-1-carboxylate. We
showed that a MPS coating of 21 nm in thickness is sufficient to electrically insulate and provide
immobilization surface to the PEMS for in-liquid electrical self-excitation and self-sensing. The
in-phosphate buffered saline solution resonance spectra were stable with Q values ranging from 41
to 55. The mass detection sensitivities were determined to be 5 10−11 and 8 10−12 g/Hz for the
MPS-insulated PZT-glass and PMN-PT/tin PEMSs, respectively. |
| URI: | http://dx.doi.org/10.1063/1.2727466
http://hdl.handle.net/1860/1657 |
| Appears in Collections: | Faculty Research and Publications (MSE)
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