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Advances in vibrational spectroscopy as a sensitive probe of peptide and protein structure. A critical review
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http://hdl.handle.net/1860/1178
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| Title: | Advances in vibrational spectroscopy as a sensitive probe of peptide and protein structure. A critical review |
| Authors: | Schweitzer-Stenner, Reinhard |
| Keywords: | Raman Spectroscopy
IR Spectroscopy
VCD Spectroscopy
Peptide Structure
Coupled Oscillator Model |
| Issue Date: | 21-Feb-2006 |
| Publisher: | Elsevier Science B.V. |
| Citation: | Vibrational Spectroscopy, 42(1): pp. 98-117. http://dx.doi.org/10.1016/j.vibspec.2006.01.004 |
| Abstract: | Over the last 40 years the theoretical basis has been developed for using vibrational
spectroscopy as a tool for peptide and protein structure analysis. In spite of these efforts
it is still considered to be a low resolution technique, which cannot compete with NMR
and X-ray crystallography. However, experimental and computational developments
over the last 10 years have provided tools which make vibrational spectroscopy a much
more powerful technique. This review focuses mostly, though not exclusively, on the use
of the amide I mode for the structure analysis of polypeptides. It evaluates the physical
basis of a variety of theoretical and experimental concepts and argues that only a
combination of different techniques and spectroscopies can advance the field towards a
more precise determination of dihedral angles in even highly heterogeneous polypeptides. |
| URI: | http://hdl.handle.net/1860/1178 |
| Appears in Collections: | Faculty Research and Publications (Chemistry)
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